Graduate Programs


Faculty Research Mentors

STEFAN BALAZ, PH.D.
STEFAN BALAZ, PH.D.

Professor
(802) 735-2615
stefan.balaz@crofoottravel.com 

Dr. 巴拉兹的研究方向是发展实验和计算方法,以确定药物处置和受体结合. In disposition, 他的实验室使用替代相进行实验测量,以发现膜和甘油三酯相中跨膜转运率和积累的结构决定因素, and (2) binding to prevalent human proteins such as albumin and extracellular matrix components. The data is used to develop structure-based models for predicting the volume of distribution and other pharmacokinetic characteristics. One of the major goals of this work is to find ways to tailor drug structures for limited distribution, thereby reducing the cytotoxicity of drugs such as those used in treating some cancers or arthritis.

Christopher Cioffi, Ph.D.
Christopher Cioffi, Ph.D.

Assistant Professor
(518) 694-7224
christopher.cioffi@crofoottravel.com                                                                             

Dr. Cioffi是一名药物化学家,在支持大型制药公司的研究项目中拥有丰富的药物研发经验, biotech, academic, and NIH collaborations. He has made significant drug design contributions to programs spanning multiple therapeutic indications (e.g., dyslipidemia, irritable bowel syndrome, CNS, and ophthalmology) and has helped advance drug candidates into pre-clinical development and clinical trials. In 2018, Dr. Cioffi was named co-principal investigator on a three-year, $1.45 million NIH research grant aimed at developing novel drug compounds for treating Age-related Macular Degeneration (AMD), a leading cause of vision loss in people age 50 and older.

RICHARD E. DEARBORN, JR., PH.D.
RICHARD E. DEARBORN, JR., PH.D.

Associate Professor
(518) 694-7387
richard.dearborn@crofoottravel.com

Dr. 迪尔伯恩的研究集中在果蝇(Drosophila)发育神经生物学的三个主要领域:1)阐明维生素D3上调蛋白1 (VDUP1)在大脑发育过程中的肿瘤抑制功能, including VDUP1’s role in neural stem cell biology, 2) Hedgehog (Hh)-dependent regulation of VDUP1 in cell proliferation, including how tumor cell-specific differences in Hh signaling affect pharmacological treatment strategies, and 3) Molecular characterization of Eph receptor signaling pathways, which regulate axon guidance, vascular growth, and tumorigenesis. The lab emphasizes molecular-genetic approaches in these studies, each with clinical and translational relevance.

MARTHA A. HASS, PH.D
MARTHA A. HASS, PH.D.

Associate Professor and Director of Research
(518) 694-7238
martha.hass@crofoottravel.com

Dr. Hass’ research integrates synthetic organic chemistry, pharmaceutical formulation and stability, biochemical assays, medicinal chemistry, and pharmacology. Her laboratory provides training opportunities for students in the areas of drug synthesis, pharmaceutical formulation, topical drug delivery, and assessment of drug efficacy. A major area of focus is the synthesis and activity of new drugs for use as topical agents to treat skin diseases. 一组新颖的联合药物被设计用来补充皮肤中的天然抗氧化剂,以增强和扩展光保护相对于现有的局部产品. 其他正在开发的局部药物利用联合药物的方法来靶向角化细胞增生和银屑病相关的炎症.

Kideok Jin, Ph.D.
Kideok Jin, Ph.D.

Assistant Professor
(518) 694-7175
kideok.jin@crofoottravel.com

大约70%的雌激素受体(ER)阳性乳腺癌通过使用各种内分泌疗法显著降低了侵袭性乳腺癌的风险. Despite the relative safety and significant anti-neoplastic and chemopreventive activities of tamoxifen and aromatase inhibitors, many initially responsive breast tumors develop resistance and ultimately recur. 我目前的研究方向是在内分泌耐药乳腺癌与肿瘤微环境的串扰中,探究导致内分泌耐药的分泌组. 我的实验室的长期任务是了解内分泌耐药过程的步骤,以便开发有效预防和治疗内分泌耐药乳腺癌的治疗方法. 我研究的最终目标是将治疗方法引入临床,提高转移性乳腺癌患者的生存率.

Timothy LaRocca, Ph.D.
Timothy LaRocca, Ph.D.

Assistant Professor 
(518) 694-7332
timothy.larocca@crofoottravel.com

Dr. LaRocca’s research interest lies primarily in the mechanisms of eukaryotic programmed cell death or PCD. This includes the processes of apoptosis, necroptosis, and the molecular switches that balance the two pathways. Dr. LaRocca is particularly interested in the role of glucose in driving PCD. He is actively investigating the mechanism of hyperglycemic cell death and its role in the exacerbation of ischemic brain injury (stroke). A second project in his lab is an NIH-funded grant aimed at improving understanding of a type of red blood cell death called necroptosis and exploring ways to influence this process. 这项研究的结果有一天可能会改善对患有细菌血液感染和其他血液相关疾病患者的治疗. 

MEENAKSHI MALIK, D.V.M., PH.D.
MEENAKSHI MALIK, D.V.M., PH.D.

Professor
(518) 694-7168
meenakshi.malik@crofoottravel.com

The long term research goal of Dr. 马利克的实验室正在了解宿主病原体相互作用的复杂性,以便开发针对重要细菌感染的改进的预防和治疗药物. She has a three-year grant by the National Institutes of Health to investigate the mechanisms by which Francisella tularensis, a category A biothreat agent survives inside the immune cells and suppresses the protective immune responses. 第二个重点领域是研究导致耐甲氧西林金黄色葡萄球菌(MRSA)菌株耐药性发展的分子机制. Click the following PubMed link for additional information on research projects taking place in Dr. Malik's lab.

SHAKER A. MOUSA, PH.D., MBA, FACC, FACB
SHAKER A. MOUSA, PH.D., MBA, FACC, FACB

Professor
Chairman of m8体育 Pharmaceutical Research Institute
(518) 694-7397
shaker.mousa@crofoottravel.com

Dr. Mousa目前的研究兴趣集中在通过探索细胞粘附分子和细胞外基质蛋白的作用来推进治疗和诊断靶点的新概念, angiogenesis, thrombosis, and inflammation modulation in health and diseases. To this end, enabling technologies including nanotechnology, biotechnology, pharmacotherapy, 干细胞是发现新的治疗方法和诊断方法的关键催化剂,用于各种疾病的治疗和预防,包括肿瘤, cardiovascular, neurological, ophthalmological, inflammatory, and other vascular disorders. Visit the Pharmaceutical Research Institute website to learn more about current projects and initiatives.

MARCEL MUSTEATA, PH.D.
MARCEL MUSTEATA, PH.D.

Associate Professor
(518) 694-7883
marcel.musteata@crofoottravel.com

Dr. Musteata's research interests include the development of miniaturized analytical technology for
pharmacokinetic studies and therapeutic drug monitoring, with the purpose of creating personalized therapeutic
devices that integrate chemical analysis, decision, and drug delivery.

Manish B. Shah, Ph.D.
Manish B. Shah, Ph.D.

Assistant Professor
(518) 694-7343
manish.shah@crofoottravel.com

Work in Dr. Shah's laboratory involves structural biology. 他目前正在使用结构和生物物理方法研究药物代谢细胞色素P450 (CYP)酶的遗传多态性. CYP's constitute the major enzyme family in drug metabolism, 氨基酸取代的单核苷酸多态性是药物反应个体间变异的重要贡献者. In brief, 重组蛋白的表达和纯化在实验室进行,以生产结晶所需的CYP蛋白的数量. The crystallographic data is collected remotely, and the three dimensional structure of the protein is then elucidated using computational tools.

BINSHAN SHI, PH.D.
BINSHAN SHI, PH.D.

Assistant Professor
(518) 694-7116
binshan.shi@crofoottravel.com

Dr. 施教授的研究兴趣主要集中在利用高级分子生物学手段了解疾病发病机制的分子基础, virology, molecular genetics, and bioinformatics approaches. Methods used in his lab include a) HIV-1 infectious molecular clone, recombinant virus, and reporter gene technologies to study HIV phenotypes such as infection and replication; b) HIV-1 single genome amplification, sequencing and bioinformatics tools to understand genotype changes and their association with disease progression. Another major area of interest in Dr. Shi’s lab is the design and development of diagnosis assays for detecting infectious diseases, monitoring disease progression, and managing treatments.

Vir Singh
Vir Singh, PH.D

Assistant Professor
(518) 694-7368
vir.singh@crofoottravel.com

Dr. Singh has an extensive scientific background in studying molecular mechanisms associated with HIV pathogenesis, genomic imprinting, molecular biology and mouse models of disease. Dr. Singh’s research interests include investigating the underlying molecular mechanisms involved in- i) HIV associated neurological disorder, ii) HIV latency, and iii) Viral infection induced developmental defects. Currently, Dr. Singh’s lab is focused at investigating two projects that come under NIH HIV/AIDS high priority research topics. 项目1:研究HIV(人类免疫缺陷病毒)介导的Sonic hedgehog (Shh)信号下调对脑内稳态的影响,特别关注星形胶质细胞和其他脑驻留细胞(大脑内皮细胞)之间的异常通信, pericytes, microglia and neurons). Project 2: To characterize select noncoding RNAs for their potential to establish HIV latency via- i) mediating Interferon signaling, and ii) regulating expression of HIV genome by epigenetic mechanisms. Successful completion of these studies will identify novel targets to alleviate HIV pathogenesis as well as pave the way towards HIV cure.

JEFFREY M. VOIGT, PH.D.
JEFFREY M. VOIGT, PH.D.

Associate Professor
(518) 694-7308
jeffrey.voigt@crofoottravel.com

VDUP-1 (TBP-2) is a protein whose expression is decreased in tumors and increased following treatment with Vitamin D. VDUP-1 functions as an inhibitor of thioredoxin, which interacts with a number of transcription factors. Dr. Voigt目前正在研究VDUP-1在不同细胞类型中调控转录因子活性和细胞增殖/分化的作用.

ERIC YAGER, PH.D.
ERIC YAGER, PH.D.

Assistant Professor
(518) 694-7110
eric.yager@crofoottravel.com

Research in Dr. Yager’s laboratory is focused on understanding how the body regulates inflammatory responses during flu infection. 最近的研究已经确定了多蛋白胞质NLPR3炎症小体复合物在流感感染期间宿主防御和病理生理中的重要作用. Specifically, Dr. Yager和他的团队正在研究NLRP3炎症小体激活和由此产生的炎症细胞因子分泌是如何在分子水平上受到调控,从而有利于宿主保护而不是免疫病理学. 其他研究领域包括确定新靶点,用于开发新的抗病毒药物以对抗流感感染,以及病毒诱导的炎症在自闭症谱系障碍的病因和发病机制中的作用.

Haian Zheng, Ph.D.
Haian Zheng, Ph.D.

Associate Professor
(518) 694-7895
haian.zheng@crofoottravel.com

Dr. Zheng’s research group is interested in the design and evaluation of Complex Drug Products (CDP) that are made of botanicals, peptides, and proteins from nature. Interdisciplinary technologies and translational strategies are used to ensure pharmaceutical quality, elucidate mechanisms of action, and evaluate clinical benefits and risks. These efforts can help empower regulatory decisions and enable patient-centric product design. Current projects in the lab focus on assessing the risks and benefits of medical cannabis products. 这包括研究植物和内源性大麻素对大脑和血脑接口(BBI)的影响,以及研究内源性大麻素系统(ECS)对药物传递障碍的影响.